Treatment Center Directory

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Treatment Center Directory

Search the AMVUTTRA® Treatment Center Directory to locate the treatment center closest to your patient

Treatment Center Directory

Search the AMVUTTRA® Treatment Center Directory to locate the treatment center closest to your patient

 
 

The AMVUTTRA Treatment Center Directory is for informational purposes only. No fees or other remuneration have been or will be exchanged for a treatment center’s inclusion in this database. Inclusion of centers in this database will be based on opt-in approval by authorized personnel for those sites listed. Inclusion in this database does not represent an endorsement of, recommendation for, or referral to the treatment centers listed in this database by Alnylam Pharmaceuticals. Likewise, participating treatment centers do not necessarily administer or endorse any Alnylam products.

To find other treatment centers near your patient, try using the National Infusion Center Association (NICA) Locator.

Interested in being listed in the AMVUTTRA Online Treatment Center Directory?
 
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Update or remove your contact information from this directory.

Important Safety Information

Reduced Serum Vitamin A Levels and Recommended Supplementation

AMVUTTRA treatment leads to a decrease in serum vitamin A levels.

Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking AMVUTTRA. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with AMVUTTRA, as serum vitamin A levels do not reflect the total vitamin A in the body.

Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g., night blindness).

Adverse Reactions

In a study of patients with hATTR-PN, the most common adverse reactions that occurred in patients treated with AMVUTTRA were pain in extremity (15%), arthralgia (11%), dyspnea (7%), and vitamin A decreased (7%).

In a study of patients with ATTR-CM, no new safety issues were identified.

For additional information about AMVUTTRA, please see the full Prescribing Information.

Indications

AMVUTTRA® (vutrisiran) is indicated for the treatment of the:

  • cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM) in adults to reduce cardiovascular mortality, cardiovascular hospitalizations and urgent heart failure visits.
  • polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN) in adults.

For additional information about AMVUTTRA, please see the full Prescribing Information.