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With AMVUTTRA® (vutrisiran) for the treatment of the polyneuropathy
of hATTR amyloidosis in adults, your patients may1

FEEL MORE IN THE MOMENT1-3

AMVUTTRA may halt the progression of or reverse the polyneuropathy of hATTR amyloidosis with dosing 4 times per year1,3

AMVUTTRA may halt the progression of or reverse the polyneuropathy of hATTR amyloidosis with dosing 4 times per year1,3

AMVUTTRA may halt the progression of or reverse the polyneuropathy of hATTR amyloidosis with dosing 4 times per year1,3

At 9 months in a randomized, open-label study, patients treated with AMVUTTRA once every 3 months were compared with an external placebo group and demonstrated:

Improvement in neuropathy impairment, as measured by mNIS+71,3

Improvement in quality of life, as measured by Norfolk QoL-DN1,3

Improvement in gait speed, as measured by 10MWT1,3

10MWT=10-meter walk test; hATTR=hereditary transthyretin-mediated; mNIS+7=modified Neuropathy Impairment Score + 7; Norfolk QoL-DN=Norfolk Quality of Life-Diabetic Neuropathy.

Explore the pivotal study design and the efficacy and safety of AMVUTTRA

Learn how to administer AMVUTTRA

Find out how to get your patients started with AMVUTTRA

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Important Safety Information and Indication

Important Safety Information

Reduced Serum Vitamin A Levels and Recommended Supplementation

AMVUTTRA® (vutrisiran) treatment leads to a decrease in serum vitamin A levels.

Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking AMVUTTRA. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with AMVUTTRA, as serum vitamin A levels do not reflect the total vitamin A in the body.

Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g., night blindness).

Adverse Reactions

The most common adverse reactions that occurred in patients treated with AMVUTTRA were pain in extremity (15%), arthralgia (11%), dyspnea (7%), and vitamin A decreased (7%).

Indication

AMVUTTRA is indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.

For additional information about AMVUTTRA, please see the full Prescribing Information.

References

  1. AMVUTTRA Prescribing Information. Cambridge, MA: Alnylam Pharmaceuticals, Inc.
  2. Vinik EJ, Vinik AI. In: Farquhar I, Summers KH, Sorkin A, eds. The Value of Innovation: Impact on Health, Life Quality, Safety, and Regulatory Research. Bingley, UK: Emerald Group Publishing Ltd; 2007;16:29-52.
  3. Adams D, Tournev IL, Taylor MS, et al. Amyloid. 2022. Published online July 23, 2022. doi.org/10.1080/13506129.2022.2091985.